20230928 Longevity Research Update; Stem Cell Improvement!
Cellular senescence Cellular senescence is a state of permanent cell cycle arrest that occurs in response to a variety of stimuli, including DNA damage, telomere shortening, and oxidative stress. Senescent cells are metabolically active and can secrete a variety of pro-inflammatory and pro-tumorigenic factors, which can contribute to aging and age-related diseases. Stemness is the ability of a cell to self-renew and differentiate into different types of cells. Stem cells are essential for tissue development, repair, and regeneration. However, the ability of stem cells to self-renew and differentiate decreases with age. Cellular senescence and stemness are interconnected in a number of ways. Senescent cells can inhibit the proliferation and differentiation of stem cells. Stem cells can differentiate into senescent cells. Senescent cells can accumulate in stem cell niches, displacing stem cells and impairing their function. The pro-inflammatory and pro-tumorigenic fac...